Citrus species (Citrus spp.), such as orange, lemon, and grapefruit, have a long history of use in traditional medicine systems for a variety of ailments, including edema. In folk medicine, especially in regions such as Asia and the Mediterranean, citrus peels, leaves, and juices have been used as mild diuretics to help reduce water retention and swelling associated with edema. The traditional rationale often rests on the presence of flavonoids, vitamin C, and essential oils, which are believed to promote diuresis and support vascular health.

However, scientific validation of these traditional uses remains limited. A few animal studies and in vitro experiments suggest that certain flavonoids (e.g., hesperidin, naringenin, and diosmin) present in citrus fruits may have mild diuretic, vasoprotective, and anti-inflammatory effects, but direct clinical evidence for the efficacy of Citrus spp. specifically in treating edema in humans is lacking. Most modern diuretic therapies rely on pharmaceutical agents with well-established efficacy and safety profiles.

In summary, while the use of Citrus spp. for edema has a basis in traditional medicine, current scientific evidence is insufficient to support its effectiveness for this condition. More rigorous clinical trials are needed to substantiate traditional claims.