Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Centella triterpenes, the active compounds extracted from Centella asiatica (commonly known as gotu kola), have been investigated for their effects on venous insufficiency and related edema. Several clinical studies and reviews support the use of Centella triterpenes, particularly madecassoside and asiaticoside, in managing chronic venous insufficiency (CVI), which frequently presents with lower limb edema. The proposed mechanisms include strengthening of the vascular wall, improvement of microcirculation, and reduction of capillary filtration. A meta-analysis published in Phytomedicine (2013) and studies in journals such as Angiology and International Journal of Angiology have reported that Centella triterpenes can significantly reduce edema, increase venous tone, and decrease capillary permeability in patients with CVI. These effects are attributed to the stimulation of collagen synthesis and improvement of connective tissue integrity in blood vessels. While most evidence comes from small to moderate-sized human trials, the consistent clinical findings and plausible pharmacological actions provide a reasonable scientific basis for using Centella triterpenes in the supportive management of edema related to venous insufficiency. However, more large-scale and high-quality randomized controlled trials are needed to further clarify their efficacy and safety profile.

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