Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Glycyrrhiza (commonly known as licorice root) has a long history of traditional use for digestive complaints, including dyspepsia. Traditional medical systems such as Traditional Chinese Medicine (TCM), Ayurveda, and European herbal medicine have recommended licorice root preparations for soothing gastrointestinal irritation, promoting mucosal healing, and relieving symptoms such as heartburn, bloating, and mild stomach discomfort. The demulcent (soothing) properties of licorice are attributed mainly to glycyrrhizin and related compounds, which may help protect the gastric mucosa. Deglycyrrhizinated licorice (DGL) is a specific preparation used traditionally and now sometimes in modern herbal practice for dyspepsia, gastritis, and peptic ulcers.

Scientific evidence for Glycyrrhiza’s efficacy in dyspepsia is limited but suggestive. Some small clinical trials and experimental studies (mostly on DGL rather than whole licorice) indicate a potential benefit in reducing gastric irritation and promoting ulcer healing, but high-quality, large-scale randomized controlled trials are lacking. Safety concerns—particularly with long-term or excessive use due to glycyrrhizin’s mineralocorticoid effects—mean that traditional use is generally favored over routine clinical recommendation. Overall, the use of Glycyrrhiza for dyspepsia is primarily justified by tradition, with moderate but not conclusive supporting evidence.

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