Evidence supporting the use of: Vitamin B6 (pyridoxine phosphate)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Vitamin B6 (pyridoxine phosphate) has traditionally been used to alleviate symptoms associated with dysmenorrhea (painful menstruation), largely based on its established role in neurotransmitter synthesis and modulation of hormonal activity. Historically, practitioners of complementary and alternative medicine have recommended B6 supplementation to help manage premenstrual and menstrual symptoms, including cramps and mood disturbances. The rationale stems from the vitamin's involvement in the synthesis of serotonin and gamma-aminobutyric acid (GABA), neurotransmitters thought to influence pain perception and mood regulation.

However, scientific evidence specifically supporting the use of Vitamin B6 for dysmenorrhea is limited. Most clinical research has focused on its role in premenstrual syndrome (PMS), where some studies indicate modest benefit for mood-related symptoms but not consistently for menstrual pain. High-quality randomized controlled trials directly investigating Vitamin B6 for dysmenorrhea are lacking, and existing studies are often small, poorly controlled, or inconclusive. Thus, while traditional use persists and there is a plausible biochemical basis, robust scientific validation for its efficacy in treating dysmenorrhea is not currently available.

In summary, Vitamin B6 is used primarily based on traditional practices and theoretical mechanisms, with limited direct scientific evidence to support its effectiveness for dysmenorrhea.

More about Vitamin B6 (pyridoxine phosphate)
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