Evidence supporting the use of: Vitamin B6
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting or treating dysmenorrhea, which is characterized by painful menstrual cramps. The rationale for its use is primarily based on its involvement in neurotransmitter synthesis, particularly serotonin and gamma-aminobutyric acid (GABA), which may influence pain perception and mood regulation. Some studies suggest that B6 may help alleviate symptoms related to premenstrual syndrome (PMS), such as mood changes, which often overlap with dysmenorrhea, though its effect on pain specifically is less clear.

Clinical evidence directly supporting vitamin B6 for dysmenorrhea is limited and not robust. A few small randomized controlled trials have evaluated its effect, with some indicating modest reductions in pain intensity, but these are often confounded by methodological limitations, such as small sample sizes, lack of blinding, or use of combination therapies (e.g., B6 with magnesium). Systematic reviews generally conclude that while B6 may have a role in PMS symptom relief, evidence for its efficacy in dysmenorrhea specifically is weak or inconclusive.

Overall, the use of vitamin B6 for dysmenorrhea is supported by a plausible biological mechanism and some preliminary clinical data, but high-quality evidence is lacking. Most guidelines do not recommend B6 as a first-line treatment for dysmenorrhea, and further research is needed to establish its efficacy and optimal dosing.

More about vitamin B6
More about Dysmenorrhea

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