Evidence supporting the use of: Proprietary Blend (Fatty Acid or Fat/Oil supplement)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fatty acid or fat/oil supplements—most notably omega-3 polyunsaturated fatty acids such as those found in fish oil—have been studied for their potential benefits in managing dysmenorrhea. Omega-3 fatty acids are thought to exert anti-inflammatory effects by modulating prostaglandin synthesis, which may be relevant because elevated prostaglandins are implicated in the pathophysiology of menstrual pain.

Several randomized controlled trials and meta-analyses have examined the impact of omega-3 supplementation on dysmenorrhea. A 2018 meta-analysis (Rahbar et al., 2018, Obstetrics & Gynecology Science) found that omega-3 supplementation was associated with a reduction in the severity of menstrual pain compared to placebo. Similar results have been observed in smaller individual studies, where omega-3 fatty acids either alone or in combination with vitamin E reduced pain intensity and the need for additional analgesic medications. The proposed mechanism is decreased synthesis of pro-inflammatory prostaglandins (mainly PGF2α), which are responsible for uterine contractions and pain during menstruation.

While these findings are promising, the quality of evidence is moderate, with some studies limited by small sample sizes and variations in dosing and duration. Nonetheless, the use of omega-3 fatty acids as a supportive approach for dysmenorrhea has some scientific validation, though more large-scale trials are needed to establish optimal dosing and long-term efficacy.

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