Evidence supporting the use of: Phytocannabinoid (unspecified)
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phytocannabinoids, primarily cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), are active compounds found in cannabis. Their use for dysmenorrhea (painful menstruation) has gained interest in recent years, largely due to their established analgesic and anti-inflammatory properties. While cannabis has a long history of use in traditional medicine for various types of pain, specific historical documentation of its use for menstrual cramps is limited, though some sources suggest it was used for female reproductive issues in the 19th century.

In terms of scientific evidence, there are currently no large, high-quality randomized controlled trials specifically evaluating phytocannabinoids for dysmenorrhea. However, some studies have demonstrated that cannabinoids can modulate pain perception by interacting with the endocannabinoid system, which is involved in pain signaling pathways. Preclinical studies and limited human research suggest cannabinoids may be effective for certain types of chronic pain, including neuropathic pain.

Anecdotal reports and small surveys indicate that some women self-medicate with cannabis to manage menstrual pain, often citing improvements in symptoms. However, clinical guidelines do not currently recommend phytocannabinoids for dysmenorrhea due to insufficient direct evidence. Therefore, while there is a plausible biological rationale and growing interest, robust clinical evidence is lacking, resulting in a low evidence rating for this specific indication.

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