Evidence supporting the use of: Five-leaf Chastetree
For the health condition: Dysmenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Five-leaf Chastetree (Vitex negundo) has a long-standing history of traditional use in various systems of medicine, particularly in Ayurveda and traditional Chinese medicine, for the relief of gynecological ailments, including dysmenorrhea (painful menstruation). The leaves, seeds, and roots are commonly used in decoctions or extracts aimed at alleviating menstrual pain and regulating menstrual cycles. Ethnobotanical surveys and traditional medicine literature frequently cite Vitex negundo as a remedy for menstrual discomfort, and its use is widespread in India and Southeast Asia for this purpose.

However, scientific validation for these uses is limited. While some preclinical studies suggest that extracts from Vitex negundo may possess anti-inflammatory, analgesic, and spasmolytic properties—mechanisms potentially relevant to dysmenorrhea—there is a lack of robust clinical trials specifically investigating its effectiveness for menstrual pain in humans. Most scientific evidence is either anecdotal or based on animal models, and systematic reviews or meta-analyses supporting its efficacy for dysmenorrhea are lacking. Therefore, the primary justification for its use remains traditional rather than scientifically validated.

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