Synopsis

Source of validity: Traditional
Rating (out of 5): 2

American Wormseed (Dysphania ambrosioides, formerly Chenopodium ambrosioides) has a long history of use in traditional medicine across the Americas, particularly in indigenous and folk systems. Historically, its seeds and leaves were employed as a remedy for various intestinal ailments, especially for expelling intestinal worms (hence the common name "wormseed"). It was also sometimes used for gastrointestinal complaints such as dysentery and diarrhea. The rationale stemmed from its reputed antimicrobial and antiparasitic properties, as well as its ability to reduce intestinal discomfort.

However, scientific evidence supporting its effectiveness specifically for dysentery (an infection causing bloody diarrhea, often due to Shigella or Entamoeba histolytica) is sparse. Most of the available literature and ethnobotanical records describe its use for general intestinal cleansing and as an anthelmintic, rather than explicitly for bacterial or amoebic dysentery. Few, if any, controlled clinical trials have evaluated American Wormseed for dysentery. Laboratory studies have shown that some constituents (notably ascaridole) possess antimicrobial properties, but toxicity concerns (including neurotoxicity and hepatotoxicity from ascaridole) have limited its use and further research.

In summary, the use of American Wormseed for dysentery is grounded in tradition rather than robust scientific evidence. Its historical use reflects broader applications for intestinal issues, but there is limited direct support for its efficacy or safety in treating dysentery.

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