Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice (primarily Glycyrrhiza glabra) has a long history of traditional use for digestive complaints, including duodenal ulcers. More importantly, there is also scientific evidence supporting its use. The deglycyrrhizinated form of licorice (DGL) is of particular interest, as it reduces the risk of glycyrrhizin-related side effects (e.g., hypertension, hypokalemia) while maintaining gastrointestinal benefits. Several clinical studies and reviews have demonstrated that DGL can promote mucosal healing and reduce ulcer-related symptoms. The proposed mechanisms include enhancement of mucus production, increased blood supply to the gastric mucosa, and stimulation of growth and regeneration of the gastrointestinal lining. Randomized controlled trials (RCTs) from the 1960s-1980s reported that DGL was as effective as some standard therapies of the time in healing duodenal ulcers, with fewer side effects. However, the evidence base is limited by the age and methodological quality of these studies, and there have been few recent high-quality RCTs. Nevertheless, licorice (especially DGL) remains a well-known alternative or adjunctive therapy for duodenal ulcers, supported by both mechanistic studies and moderate clinical data. It is not recommended as a sole therapy for severe ulcers but may be considered as part of an integrative approach.

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