Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tyrosine alpha-ketoglutarate is a compound combining the amino acid L-tyrosine and alpha-ketoglutarate, a molecule involved in the Krebs cycle. L-tyrosine itself is a well-established precursor for catecholamine neurotransmitters, including dopamine, norepinephrine, and epinephrine. Supplementation with L-tyrosine is thought to support dopamine synthesis, particularly under conditions where catecholamine stores may be depleted, such as stress or prolonged cognitive demand. Some studies have shown that L-tyrosine supplementation can help maintain cognitive function and mood during acute stress, likely due to its role in dopamine production.

However, there is limited direct research on tyrosine alpha-ketoglutarate specifically. Most evidence supporting its use comes from studies on L-tyrosine alone. The addition of alpha-ketoglutarate may enhance absorption or metabolism, but this synergy has not been robustly validated in human trials. Therefore, while there is a scientific rationale for using L-tyrosine to support dopamine-related processes, the evidence for tyrosine alpha-ketoglutarate itself is limited. The overall evidence for its use to support the "dopamine body system" can be considered modest, warranting a rating of 2 out of 5.

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