Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sceletium tortuosum, commonly known as kanna, is a succulent plant native to South Africa. Traditionally, it has been used by indigenous Khoisan peoples for its mood-enhancing effects. The plant was chewed, smoked, or used as a tea to help alleviate stress, anxiety, and feelings of depression, which are often associated with disturbances in the dopamine system. Historical accounts and ethnobotanical reports suggest that Sceletium was believed to provide relaxation and promote mental well-being.

While some laboratory and animal studies indicate that Sceletium alkaloids (such as mesembrine) can inhibit the reuptake of serotonin and, to a lesser extent, dopamine, direct scientific validation in humans remains limited. There are only a few small clinical trials, and most have focused on general mood and anxiety rather than specifically targeting dopamine pathways. Therefore, its use to support the dopamine body system is primarily justified by traditional use rather than robust scientific evidence.

In summary, Sceletium is used for its mood-lifting properties based on a long history of traditional use, with some preliminary scientific rationale. However, strong clinical evidence for its specific support of the dopamine system is lacking at this time.

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