Phosphatidylserine is a phospholipid that is found in high concentrations in the brain and plays a key role in cell membrane fluidity and signaling. Its use as a supplement is primarily based on its effects on cognitive function and memory, rather than direct support of the dopaminergic system. However, there is some scientific evidence suggesting phosphatidylserine may influence neurotransmitter systems, including dopamine, particularly in the context of cognitive decline and stress response.

Some animal studies have shown that phosphatidylserine supplementation can increase dopamine levels in the brain, mainly in aged rats, potentially by supporting neuronal membrane integrity and promoting neurotransmitter release. Limited human studies suggest that phosphatidylserine may help reduce cognitive decline and improve memory in elderly individuals, and there is some evidence of reduced stress-induced elevations of cortisol, which can indirectly affect dopamine signaling. However, direct evidence in humans linking phosphatidylserine supplementation to significant improvements in dopamine-related functions or disorders is sparse.

In summary, while there is some scientific rationale and limited preclinical evidence suggesting phosphatidylserine could support aspects of the dopamine system, the evidence is not strong or direct. The primary support for its use comes from its general effects on cognitive health rather than targeted dopaminergic mechanisms.