The hypothalamus is a critical brain region involved in regulating the dopamine system. It is not an "ingredient" per se, but in scientific and medical literature, it is frequently referenced for its regulatory role in dopamine pathways. The hypothalamus produces and releases several hormones and neuropeptides that influence dopamine synthesis, release, and signaling, particularly through its connections with the pituitary gland and other brain regions. For example, the tuberoinfundibular pathway, which originates in the hypothalamus, regulates the secretion of prolactin via dopaminergic neurons. Additionally, the hypothalamus interacts with the mesolimbic and mesocortical dopamine systems, which are involved in motivation, reward, and emotional regulation.

Numerous studies have demonstrated that hypothalamic dysfunction can impact dopamine levels and related physiological processes, such as appetite, stress response, thermoregulation, and reproductive behaviors. There is robust scientific evidence supporting the role of the hypothalamus in modulating dopamine activity and, by extension, various bodily systems influenced by dopamine. However, it is important to note that the hypothalamus itself is not used as a supplement or ingredient, but rather is studied as a key regulatory center in the body’s endogenous dopamine system.