Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citicoline (also known as CDP-choline) is a compound that serves as an intermediate in the synthesis of phosphatidylcholine, a key component of cell membranes. It is also a source of choline, which is a precursor to the neurotransmitter acetylcholine. Regarding the dopamine system, citicoline has been studied for its potential to support dopaminergic neurotransmission. Research suggests that citicoline can enhance dopamine release and increase dopamine receptor densities, particularly in the striatum, a brain region involved in motor control and reward pathways. This has led to its investigation in conditions involving dopamine dysfunction, such as Parkinson’s disease, cognitive decline, and certain types of drug addiction.

Human clinical trials have yielded mixed but generally positive results, with some studies indicating that citicoline supplementation may improve cognitive function, attention, and memory, possibly through modulation of dopamine levels. However, the evidence is not uniform across all studies, and many trials have small sample sizes or methodological limitations. Despite this, the mechanistic rationale for citicoline’s role in supporting the dopamine system is supported by animal and human studies demonstrating increased dopamine synthesis and receptor availability. Therefore, its use for dopaminergic support is based on a moderate level of scientific evidence, meriting a rating of 3 out of 5.

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