Celastrus paniculatus, often referred to as the "intellect tree," has a long history of use in traditional Ayurvedic medicine, primarily for its purported cognitive-enhancing, neuroprotective, and adaptogenic properties. Ancient texts and ethnobotanical records describe the use of Celastrus seeds and oil to support mental clarity, memory, and mood, which aligns with the modern understanding of the dopamine system’s role in motivation, reward, and cognitive function. The seeds were often recommended for "weakness of the brain" or for those suffering from mental fatigue.

Scientific studies on Celastrus paniculatus are limited, especially regarding its effects on the dopaminergic system specifically. Some preclinical animal studies have indicated potential neuroprotective effects, including reduced oxidative damage and improved learning and memory, but these studies do not directly confirm a mechanism involving dopamine modulation. There is a lack of robust clinical trials in humans substantiating its efficacy or safety for supporting dopamine function. As a result, the traditional use of Celastrus to support cognitive or mood-related functions is recognized, but there is insufficient scientific validation to firmly establish its role in modulating the dopamine system.