Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacteria, specifically in the form of probiotics, have been explored as a supportive treatment for diverticulitis, primarily to prevent recurrent episodes rather than to treat acute inflammation. The rationale stems from the role of gut microbiota in maintaining intestinal health and modulating inflammation. Several small clinical trials and observational studies have investigated whether probiotic supplementation can reduce symptoms or recurrence of diverticular disease. Some studies have shown modest benefits, such as decreased abdominal pain and improved bowel habits, particularly in diverticular disease without acute infection (diverticulosis or symptomatic uncomplicated diverticular disease). However, the evidence for probiotics' effectiveness in acute diverticulitis remains limited and inconsistent. Current clinical guidelines suggest that while probiotics are generally safe, there is insufficient high-quality evidence to recommend them routinely for the treatment of acute diverticulitis. Most recommendations highlight the need for further large-scale, randomized controlled trials to establish clear benefits. Thus, while there is some scientific rationale and preliminary evidence supporting the use of certain beneficial bacteria for preventing recurrence or alleviating mild symptoms, the overall strength of evidence is low, and probiotics are not considered a replacement for conventional therapy during acute episodes.

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