Evidence supporting the use of: Melia (unspecified)
For the health condition: Diphtheria

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

There is traditional use of Melia species, particularly Melia azedarach (commonly known as Chinaberry), in the support or treatment of diphtheria, primarily within South Asian, Ayurvedic, and some traditional Chinese medicine systems. Historical texts and ethnobotanical surveys note that various parts of the plant, such as the bark, leaves, and fruits, have been used as remedies for throat infections, including diphtheria-like illnesses, often due to their purported antimicrobial and anti-inflammatory properties. Recipes sometimes include decoctions or topical applications. However, these uses are based on empirical tradition rather than modern clinical validation.

Scientific evidence supporting the efficacy or safety of Melia species in the treatment of diphtheria is extremely limited. A handful of in vitro studies have shown that extracts of Melia azedarach possess some antibacterial activity, but none have specifically targeted Corynebacterium diphtheriae, the causative agent of diphtheria, nor have there been any animal models or human clinical trials substantiating its use. Furthermore, parts of the Melia plant are known to be toxic if ingested improperly. Thus, while traditional usage is documented, the evidence base is weak and does not meet modern standards for medical recommendation.

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