Henna (Lawsonia inermis) has been traditionally used in various cultures for its purported medicinal properties, including the treatment of skin conditions like diaper rash. Traditional use is primarily documented in Middle Eastern and South Asian regions, where henna is applied as a topical paste to soothe skin irritation, reduce inflammation, and promote healing. The antimicrobial and cooling properties attributed to henna have made it a home remedy for minor burns, wounds, and rashes, including diaper rash in infants. However, scientific evidence supporting these uses is limited.

Some laboratory studies have demonstrated that henna extracts possess antibacterial and antifungal properties, which could theoretically benefit skin affected by diaper rash. Additionally, henna contains lawsone, a compound with mild anti-inflammatory effects. Despite these findings, there are few, if any, rigorous clinical trials evaluating the safety and efficacy of henna specifically for diaper rash in infants. Traditional use persists in some communities, but concerns remain regarding potential allergic reactions or skin sensitivity, particularly in infants with delicate skin. As a result, while there is a historical and cultural precedent for using henna for diaper rash, the supporting scientific evidence is minimal, and its safety in this context has not been robustly established.