Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proanthocyanidins, a class of polyphenolic compounds found in various plants such as grapes, berries, and pine bark, have been investigated for their potential benefits in diabetic retinopathy primarily due to their antioxidant and vascular-protective properties. Some preclinical studies and limited clinical trials suggest that proanthocyanidins can reduce oxidative stress, inhibit the formation of advanced glycation end-products (AGEs), and improve microvascular health, all of which are relevant to the pathogenesis of diabetic retinopathy.

A few small-scale human studies and animal models have reported that supplementation with proanthocyanidin-rich extracts (such as those from grape seed or pine bark) may help reduce retinal capillary leakage, inhibit retinal neovascularization, and improve capillary resistance. However, these studies are generally limited by small sample sizes, short durations, and lack of rigorous controls. Systematic reviews and major clinical guidelines do not yet endorse proanthocyanidins as a standard treatment for diabetic retinopathy, highlighting the need for larger, well-designed randomized controlled trials to confirm efficacy and safety.

Overall, while some preliminary scientific evidence exists supporting a potential benefit for proanthocyanidins in diabetic retinopathy, the current level of evidence is modest. The use of proanthocyanidins for this indication remains investigational, and more robust clinical research is required before routine use can be recommended.

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