Evidence supporting the use of: Grape
For the health condition: Diabetic Retinopathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Grapes, particularly their skins and seeds, are rich in polyphenols such as resveratrol and proanthocyanidins, which have been studied for their antioxidant and vascular protective properties. Diabetic retinopathy is a diabetes complication characterized by damage to the blood vessels of the retina, primarily due to oxidative stress and inflammation. A number of preclinical studies (in vitro and animal models) suggest that grape-derived polyphenols can reduce oxidative stress, inhibit vascular endothelial growth factor (VEGF) expression, and protect retinal cells from hyperglycemia-induced damage. For example, resveratrol has been shown to inhibit retinal neovascularization and reduce vascular leakage in diabetic rodents. Some small-scale human studies and clinical trials have investigated the broader vascular benefits of grape polyphenols, though direct, robust clinical evidence specifically for diabetic retinopathy in humans is limited. While traditional medicine systems may use grapes for general eye or vascular health, the rationale for their use in diabetic retinopathy is primarily based on scientific investigations into their bioactive components. However, the strength of clinical evidence is moderate at best, with most support coming from laboratory and early-stage clinical research. As such, while the mechanism is plausible and animal data are promising, more large-scale, high-quality human trials are needed to conclusively establish efficacy for this particular condition.

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