Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bioflavonoids, also known as flavonoids, are a diverse group of plant-derived compounds with antioxidant properties. Their use in diabetic retinopathy is supported by some scientific evidence, although the data is not robust, especially when the specific type of bioflavonoid is unspecified. Several studies and reviews have examined the effects of certain bioflavonoids, such as rutin, quercetin, and hesperidin, on microvascular complications of diabetes, including retinopathy. These compounds have demonstrated the ability to reduce oxidative stress, strengthen capillaries, and inhibit inflammation, all of which play a role in the pathogenesis of diabetic retinopathy.

Clinical trials have shown that some bioflavonoids may help reduce retinal vascular permeability and prevent damage to retinal vessels in diabetic patients. For example, some small studies using standardized mixtures (like Oxerutins or diosmin-hesperidin combinations) have reported a positive effect on retinal hemorrhages and microaneurysms. However, large, high-quality randomized controlled trials are lacking, and the benefit appears modest. The evidence is weaker when the specific type of bioflavonoid is not identified, as flavonoids vary widely in their bioactivity.

Overall, while there is a scientific rationale and some preliminary evidence for the use of certain bioflavonoids in diabetic retinopathy, the quality and consistency of the evidence is limited, especially for unspecified bioflavonoids. Thus, it receives a low-to-moderate evidence rating.

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