Vitamin E, particularly in the form of tocopherol or its esters, is sometimes used topically or in supplements to support skin health and manage dermatitis. The rationale is based on Vitamin E’s antioxidant properties, which may help neutralize free radicals, reduce oxidative stress, and modulate inflammatory processes in the skin. Some small studies and case reports have suggested that topical Vitamin E can improve symptoms of atopic dermatitis or other eczematous conditions, such as reducing itching or scaling. For example, a randomized controlled trial published in the International Journal of Dermatology (2015) reported some symptomatic relief in atopic dermatitis patients treated with oral Vitamin E compared to placebo.

However, the overall quality and quantity of evidence is limited. Most studies have small sample sizes, variable formulations, and short durations. Meta-analyses and systematic reviews typically conclude that while Vitamin E may have a potential adjunctive role, robust clinical evidence is lacking. There are also concerns about contact dermatitis reactions to Vitamin E in some individuals, which may limit its use topically.

Tocopherol ascorbyl palmitate is a compound that includes both Vitamin E (tocopherol) and a form of Vitamin C (ascorbyl palmitate), both of which are antioxidants. While theoretically beneficial, direct evidence specific to tocopherol ascorbyl palmitate for dermatitis is minimal. Overall, the use of Vitamin E for dermatitis has some scientific rationale and limited supportive evidence, but it is not considered a primary or strongly validated treatment.