Vitamin E, comprising mixed tocopherols and tocotrienols, has been investigated for its potential benefits in supporting or treating dermatitis, particularly due to its antioxidant and anti-inflammatory properties. Some small clinical studies and case reports suggest that topical or oral vitamin E may help reduce symptoms of atopic dermatitis and other eczematous conditions by decreasing oxidative stress and modulating inflammatory responses in the skin. For example, limited trials have demonstrated that oral vitamin E supplementation can lead to a modest reduction in eczema severity scores and improved skin barrier function. Its topical application has also been associated with reduced itching and lesion severity in some patients.

However, the scientific evidence remains limited and somewhat inconsistent. Most studies are small, lack rigorous controls, or use vitamin E in combination with other agents, making it difficult to attribute effects solely to vitamin E. Systematic reviews and guidelines generally conclude that, while vitamin E has a plausible biological rationale for use in dermatitis due to its antioxidative activity, the quality and quantity of evidence are insufficient to make strong clinical recommendations. More well-designed, large-scale randomized controlled trials are needed to definitively establish its efficacy and safety in dermatitis treatment.

In summary, there is some scientific basis for the use of vitamin E in dermatitis, but current evidence is weak to moderate at best.