Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (including mixed tocopherols and tocotrienols) has been investigated for its role in supporting or treating dermatitis, particularly atopic dermatitis. The rationale for its use stems from its antioxidant and anti-inflammatory properties, which may help reduce oxidative stress and inflammation involved in skin disorders. Several small clinical trials and animal studies have evaluated oral and topical vitamin E in dermatitis patients.

A few randomized controlled trials (RCTs) have shown some benefit. For example, a 2015 study (J Res Med Sci) found that oral vitamin E supplementation (400 IU/day) for 8 months significantly reduced the severity and extent of atopic dermatitis compared to placebo. Another RCT (Int J Dermatol, 2010) reported that topical vitamin E improved symptoms of chronic skin lesions. However, other studies have reported minimal or no significant effects, and methodological limitations, small sample sizes, and variable dosing make the evidence inconsistent.

Systematic reviews generally conclude that while vitamin E shows potential, the evidence is limited and not robust enough to recommend it as a primary or sole treatment for dermatitis. It may be considered as an adjunct therapy, particularly in mild cases or for patients seeking alternative or supplemental options. There is little evidence specifically regarding the efficacy of tocotrienols, as most studies focus on alpha-tocopherol. Overall, while there is some scientific rationale and modest clinical support, the evidence base is weak to moderate.

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