Vitamin E (specifically as mixed tocopherols, including alpha-tocopherol) has been studied for its potential benefits in managing dermatitis, particularly atopic dermatitis. The rationale for its use stems from its antioxidant properties, which can help reduce oxidative stress and inflammation in the skin. Several small clinical trials and animal studies suggest that both topical and oral Vitamin E may have a modest effect on symptom improvement, such as reducing erythema, itching, and lesion severity. For example, a double-blind placebo-controlled study published in International Journal of Dermatology (2015) found that oral Vitamin E supplementation led to a statistically significant improvement in clinical symptoms of atopic dermatitis compared to placebo. Case reports and some older studies also support a role for topical Vitamin E in reducing irritation and promoting skin barrier repair.

However, the overall quality and consistency of evidence are limited. Many studies have small sample sizes, short duration, or lack rigorous controls. Systematic reviews generally conclude that while there is some evidence of benefit, it is not strong enough to unequivocally recommend Vitamin E as a primary therapy for dermatitis. Thus, its use is sometimes considered as an adjunct to established treatments rather than a standalone therapy. Importantly, Vitamin E is widely regarded as safe for topical and oral use at recommended doses, but rare cases of contact dermatitis from topical formulations have been reported.