Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B5, also known as pantothenic acid, has some scientific rationale for use in supporting dermatitis, but the evidence is limited and not robust. Pantothenic acid is an essential nutrient involved in skin barrier function and wound healing, which forms the biological basis for its consideration in skin disorders, including dermatitis. Some small clinical studies and animal models suggest that topical or oral vitamin B5 (often in the form of its derivative, dexpanthenol) may improve skin hydration, enhance barrier repair, and reduce symptoms such as itching and inflammation. For example, dexpanthenol creams are commonly used in Europe for minor skin irritations and have been shown to support skin healing in mild cases of irritant contact dermatitis and diaper rash. However, large, high-quality randomized controlled trials specifically investigating vitamin B5 for atopic dermatitis or other chronic forms of dermatitis are lacking. Systematic reviews often conclude that while topical B5 may help with mild, acute skin irritation, the overall evidence for its use in chronic dermatitis is weak. Thus, vitamin B5 is used with some scientific justification, especially topically, but the clinical evidence is limited and not sufficient to make strong recommendations.

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