Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A is used in dermatology due to its essential role in skin health, particularly in cell differentiation and immune function. There is scientific rationale for its use in certain forms of dermatitis, especially those related to vitamin A deficiency, such as phrynoderma (follicular hyperkeratosis). In such cases, vitamin A supplementation can resolve skin symptoms. However, for common forms of dermatitis, such as atopic dermatitis or contact dermatitis, the evidence supporting the use of vitamin A supplementation (without specific retinoid derivatives) is limited. Most clinical studies and dermatological guidelines focus on the use of topical or systemic retinoids (synthetic derivatives of vitamin A) rather than plain vitamin A itself. These retinoids are primarily used for conditions like acne and psoriasis, with only occasional off-label use in severe, refractory cases of eczema or dermatitis. Oral vitamin A toxicity is a significant concern, limiting its use outside deficiency states. In summary, while there is a scientific basis for vitamin A’s importance in skin function, the evidence for its effectiveness in treating general dermatitis is weak, except where deficiency is present. Thus, clinical use is primarily restricted to deficiency-related dermatitis, and routine supplementation for other forms is not supported by robust research.

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