Evidence supporting the use of: Vitamin A
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin A plays a crucial role in maintaining healthy skin and supporting epithelial cell differentiation and immune function. Its use in dermatology primarily revolves around its synthetic derivatives, known as retinoids (e.g., tretinoin, isotretinoin), which are widely utilized for various skin conditions, including certain forms of dermatitis. Retinoids are FDA-approved for acne and psoriasis, but their role in the treatment of dermatitis, especially atopic dermatitis, is less established and not typically first-line therapy. Some topical retinoids may be used off-label for lichen simplex chronicus or chronic hand dermatitis due to their ability to normalize keratinization and reduce inflammation. However, direct supplementation with vitamin A (retinol or beta-carotene) for dermatitis is not well-supported by robust clinical trials, and excessive intake can be toxic. A few studies suggest that vitamin A deficiency can exacerbate skin dryness and susceptibility to irritation, potentially worsening dermatitis. However, clinical guidelines do not recommend routine vitamin A supplementation for dermatitis unless a deficiency is documented. In summary, while the biological plausibility exists and topical retinoids (vitamin A derivatives) have some utility in specific dermatologic contexts, the overall evidence base for vitamin A or its direct supplementation as a primary treatment for dermatitis is limited, supporting a low evidence rating.

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