Evidence supporting the use of: Transforming growth factor beta
For the health condition: Dermatitis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Transforming growth factor beta (TGF-β) is a multifunctional cytokine involved in regulating inflammation, cell proliferation, and tissue repair. Scientific interest in TGF-β’s role in dermatitis, particularly atopic dermatitis, is grounded in its immunomodulatory properties. Several studies have demonstrated that TGF-β can suppress pro-inflammatory cytokine production and promote the differentiation of regulatory T cells, which could theoretically reduce the inflammatory response seen in dermatitis. Additionally, TGF-β is involved in wound healing and the maintenance of skin barrier function, both of which are disrupted in various forms of dermatitis.

However, the evidence supporting the therapeutic use of TGF-β in dermatitis is still emerging and somewhat mixed. Experimental models have shown that TGF-β signaling can ameliorate dermatitis-like symptoms by dampening inflammation. For example, mouse studies indicate that enhancing TGF-β activity can reduce skin inflammation and epidermal hyperplasia. Conversely, excess TGF-β can contribute to skin fibrosis and scarring, highlighting the need for careful modulation.

To date, there are no approved clinical therapies that directly use TGF-β as a treatment for dermatitis in humans. Most of the evidence is preclinical, and clinical trials are needed to fully establish its efficacy and safety. In summary, while there is a scientific rationale and preclinical evidence for the use of TGF-β in managing dermatitis, clinical validation is limited, warranting a moderate evidence rating.

More about Transforming growth factor beta
More about Dermatitis

Other ingredients used for Dermatitis

Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
Cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
Lactoperoxidase
lauric acid
Niacinamide (vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
vitamin A
vitamin D
vitamin E
Zinc
chickweed
xanthium (cockleburs)
Mugwort
Neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
Menthol oil
melaleuca alternifolia
geranium
avens
alpha-terpineol
azelaic acid
Ardisia
anamu
Allantoin
Asteraceae
argan nut oil
bee propolis
babchi
Baphicacanthus cusia
Bidens pilosa
bishop\'s weed
Boswellic Acid
Butea monosperma
Barleria
bisabolene
bee products
Bombax
Bassia scoparia
coconut
Centella triterpenes
caryophyllene
Calendula
chlorophyllin
coconut oil
colloid
carvacrol
Curcuminoid
Chinese raisintree
curcumen
Centella asiatica
Centipeda
Curcuma
cannabidiol
Carthamus
copaiba oil
cannabigerol
chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
emu oil
Euphorbia
ethyl linoleate
flavonoids
fang-feng
fatty acids
Ficus simplicissima
fibroblast growth factor
gallic acid
Gnaphalium
glyceryl monolaurate
Glechoma hederacea
gallotannin
Glycyrrhetinic acid
heal-all
Hydrocolloid
henna
Himalaya berry
hemp
iridoid glycosides
Indian fagonia
jojoba oil
Kokilaksha
Litsea
lichen
Laggera pterodonta
linseed oil
Lantana camara
Leptospermum scoparium
Labdanum
mallow
Melia
Malva sylvestris
mangostin
Mahonia
Milkweed
Marine colloids
marigold
Marking Nut Tree
Macaranga indica
Nigella seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
Panthenol
Patrinia
Palmitoylethanolamide (PEA)
Peptides
rue
rosmarinic acid
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
Self-Heal
Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
Thymol
Tea Tree Oil
Violet
Wrightia tinctoria
Witch Hazel
Zingiberene

Products containing Transforming growth factor beta

We currently have no products on Caring Sunshine that contain this ingredient.