Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sesquiterpenes are a diverse class of terpenoid compounds found in many plants, including chamomile, yarrow, and sandalwood, and are known for their anti-inflammatory and antimicrobial properties. Their use in supporting or treating dermatitis is primarily justified by a moderate amount of scientific evidence, though most studies are preclinical or involve crude plant extracts rather than isolated sesquiterpenes.

For example, chamazulene and alpha-bisabolol, prominent sesquiterpenes in chamomile, have been shown in animal and in vitro studies to reduce inflammation and oxidative stress in skin models relevant to dermatitis. Some small clinical studies with chamomile extracts (which contain sesquiterpenes as active compounds) suggest benefit in mild atopic dermatitis and eczema, but these studies are limited in size and quality.

Other sesquiterpenes, such as farnesol and patchoulol, have demonstrated antimicrobial activity against skin pathogens, which may contribute to their supportive effects in dermatitis. However, direct evidence from large, well-controlled human trials evaluating isolated sesquiterpenes for dermatitis is lacking.

In summary, the use of sesquiterpenes in dermatitis is supported by preclinical evidence and a handful of small clinical studies using whole plant extracts. The evidence base is growing but remains limited, justifying a moderate (2/5) rating for scientific support.

More about Sesquiterpene
More about Dermatitis

Other ingredients used for Dermatitis

Other health conditions supported by Sesquiterpene

Products containing Sesquiterpene