Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a plant flavonoid found in many fruits and vegetables, and it is sometimes used as a supplement to support skin health, including conditions like dermatitis. The scientific rationale for its use is based largely on its anti-inflammatory and antioxidant properties. In vitro and animal studies have shown that quercetin can inhibit the release of pro-inflammatory cytokines and reduce oxidative stress, both of which are key contributors to the pathophysiology of dermatitis, particularly atopic dermatitis. For example, research published in Journal of Investigative Dermatology (2012) demonstrated that topical quercetin reduced inflammation and improved skin barrier function in mouse models of atopic dermatitis.

Some small-scale clinical trials and case reports have also suggested potential benefits of quercetin in reducing symptoms of allergic dermatitis and eczema in humans, primarily via topical formulations. However, the overall quality and size of these studies are limited, with few large, well-designed randomized controlled trials available to date. As a result, while there is a plausible scientific mechanism and some preliminary evidence, the overall strength of evidence supporting quercetin’s use for dermatitis remains low to moderate. It is not considered a standard treatment, and its use should be regarded as adjunctive or experimental until more robust clinical data are available.

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