Evidence supporting the use of: Polyphenols (various)
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Polyphenols, a diverse group of naturally occurring compounds found in plants (including flavonoids, phenolic acids, and tannins), have been investigated for their potential role in the management of dermatitis, especially atopic dermatitis and contact dermatitis. Scientific evidence supporting their use is moderate. Several preclinical and clinical studies suggest that polyphenols can exert anti-inflammatory, antioxidant, and immunomodulatory effects, which may alleviate symptoms of dermatitis. For example, topical application of polyphenol-rich extracts such as green tea polyphenols (EGCG), resveratrol, and curcumin has demonstrated reductions in skin inflammation, erythema, and pruritus in animal models and some small human trials. These effects are thought to result from the inhibition of pro-inflammatory cytokines (such as IL-1β, IL-6, TNF-α), suppression of NF-κB signaling, and protection against oxidative stress-induced skin damage.

However, while there are promising results, the majority of the evidence comes from laboratory and animal studies, with relatively few well-designed, large-scale clinical trials in humans. Some topical formulations are commercially available and have shown benefits in mild-to-moderate cases, but more research is needed to establish standardized dosing, long-term safety, and efficacy. In summary, the use of various polyphenols for dermatitis is scientifically plausible and supported by moderate evidence, but further clinical validation is required.

More about polyphenols (various)
More about Dermatitis

Other ingredients used for Dermatitis

Aloe vera
alpha-pinene
beeswax
beta caryophyllene
bisabolol
black currant
black walnut
burdock
Cannabis sativa oil
chamomile
coating
turmeric
forsythia
garlic bulb
ginger
gotu kola
green tea
hemp oil
hyaluronic acid
Lactoperoxidase
lauric acid
Niacinamide (vitamin B3)
oregon grape
phenolic compounds
plantain
pomegranate
purified silver
quercetin
resveratrol
riboflavin (vitamin B2)
rosemary
schizonepeta
scrophularia root
specialized pro-resolving mediators (SPMs)
Sphaeranthus indicus
vitamin A
vitamin D
vitamin E
Zinc
chickweed
xanthium (cockleburs)
Mugwort
Neem tree
commiphora
siler root
oriental arborvitae
birch
polyphenols
fulvic acid
eucalyptus
Menthol oil
melaleuca alternifolia
geranium
avens
alpha-terpineol
azelaic acid
Ardisia
anamu
Allantoin
Asteraceae
argan nut oil
bee propolis
babchi
Baphicacanthus cusia
Bidens pilosa
bishop\'s weed
Boswellic Acid
Butea monosperma
Barleria
bisabolene
bee products
Bombax
Bassia scoparia
coconut
Centella triterpenes
caryophyllene
Calendula
chlorophyllin
coconut oil
colloid
carvacrol
Curcuminoid
Chinese raisintree
curcumen
Centella asiatica
Centipeda
Curcuma
cannabidiol
Carthamus
copaiba oil
cannabigerol
chrysophanics
Dianthus
Epidermal Growth Factor
Eclipta
emu oil
Euphorbia
ethyl linoleate
flavonoids
fang-feng
fatty acids
Ficus simplicissima
fibroblast growth factor
gallic acid
Gnaphalium
glyceryl monolaurate
Growth factors
Glechoma hederacea
gallotannin
Glycyrrhetinic acid
heal-all
Hydrocolloid
henna
Himalaya berry
hemp
iridoid glycosides
Indian fagonia
jojoba oil
Kokilaksha
Litsea
lichen
Laggera pterodonta
linseed oil
Lantana camara
Leptospermum scoparium
Labdanum
mallow
Melia
Malva sylvestris
mangostin
Mahonia
Milkweed
Marine colloids
marigold
Marking Nut Tree
Macaranga indica
Nigella seed
Oxystelma
Propolis
Phyllanthus
Pentacyclic triterpenoids
Paris polyphylla
Pansit-pansitan
Panthenol
Patrinia
Palmitoylethanolamide (PEA)
Peptides
rue
rosmarinic acid
reed herb
Squalene
Sichuan Lovage
Sicklepod
Sophora
Sesbania
Solanaceae
Shark Liver Oil
Self-Heal
Sweet Annie
Salvia
Sensitive Plant
Southern Tsangshu
Silk protein
Sandalwood
Sulfur
Storax
Terpenoids
Thymoquinone
Terpinen-4-ol
Thymus
Thymol
Tea Tree Oil
Violet
Wrightia tinctoria
Witch Hazel
Zingiberene

Products containing polyphenols (various)

We currently have no products on Caring Sunshine that contain this ingredient.