Panthenol, also known as provitamin B5, is commonly used in topical formulations for skin care, including products intended for dermatitis. Scientific evidence supporting its use is moderate. Several in vitro and in vivo studies indicate that panthenol can enhance skin barrier function, improve hydration, and promote wound healing. These properties are beneficial for damaged or irritated skin, as seen in various types of dermatitis (such as atopic dermatitis and contact dermatitis).

Clinical studies have shown that topical panthenol can reduce inflammation, erythema, and itching associated with mild to moderate dermatitis. However, most studies are small, and often panthenol is used in combination with other ingredients, making it difficult to isolate its specific effect. Reviews and dermatology guidelines sometimes mention panthenol as a soothing agent for irritated or eczematous skin, but do not recommend it as a primary treatment for dermatitis.

In summary, the use of panthenol for supporting dermatitis is scientifically plausible due to its moisturizing and barrier-enhancing properties, but the clinical evidence is limited and not robust enough to assign it a high evidence rating. It is generally considered safe and may be helpful as an adjunctive, supportive skin care ingredient rather than a stand-alone therapy for dermatitis.