Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mahonia (commonly Mahonia aquifolium, also known as Oregon grape) has been used in traditional herbal medicine for skin conditions, but there is also a moderate level of scientific evidence supporting its use for dermatitis, particularly psoriasis and atopic dermatitis. Several studies have investigated topical preparations containing Mahonia extracts, focusing on their anti-inflammatory and antimicrobial properties. The active compounds, notably berberine and other alkaloids, have demonstrated the ability to inhibit pro-inflammatory cytokines and reduce keratinocyte proliferation, both of which are relevant to the pathogenesis of dermatitis.

Randomized controlled trials and open-label studies have shown that creams containing Mahonia aquifolium extract can reduce the severity of symptoms in mild to moderate psoriasis and, to a lesser extent, in atopic dermatitis. The evidence base is strongest for psoriasis, but some improvement in eczematous dermatitis has also been observed. Mahonia-based creams are generally well tolerated, with adverse effects being mild and infrequent. However, the number of high-quality, large-scale clinical trials is limited, and further research is needed to establish optimal dosing and long-term safety.

In summary, there is moderate scientific evidence that Mahonia, particularly Mahonia aquifolium, can be beneficial in treating some forms of dermatitis when used topically. Its anti-inflammatory and antimicrobial effects likely contribute to its efficacy, but it should be used as a complementary approach rather than a primary therapy until more robust evidence is available.

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Other ingredients used for Dermatitis

Other health conditions supported by Mahonia (unspecified)

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