Growth factors are proteins that play a crucial role in regulating cellular processes such as proliferation, migration, and differentiation. Their use in supporting or treating dermatitis, especially atopic dermatitis and contact dermatitis, is primarily supported by scientific research rather than traditional medicine. Several preclinical and clinical studies have explored the potential benefits of topical growth factors, such as epidermal growth factor (EGF) and fibroblast growth factors (FGFs), in enhancing skin barrier repair and modulating inflammation in dermatitis.

Scientific evidence suggests that growth factors may accelerate re-epithelialization and improve skin barrier function by promoting keratinocyte migration and proliferation. Some small clinical trials and case series have reported improvement in dermatitis symptoms, reduction in lesion size, and faster healing times with the use of topical growth factor-containing formulations. For example, studies using topical EGF have shown enhanced healing in atopic dermatitis and improvement in skin barrier recovery.

However, while the mechanistic rationale is strong and early results are promising, the evidence base is still limited by small sample sizes and a lack of large-scale, randomized controlled trials. Thus, while there is scientific support for the use of growth factors in dermatitis management, the level of evidence is moderate, and further research is necessary to establish standardized protocols and confirm efficacy and safety.