Grapeseed oil has some scientific support for its use in managing dermatitis, but the evidence is limited and largely based on its known properties and small clinical studies. Grapeseed oil is rich in linoleic acid, an essential fatty acid that helps maintain the skin barrier. Some studies suggest that topical application of oils high in linoleic acid may improve skin hydration and reduce inflammation, both of which are relevant in dermatitis conditions such as atopic dermatitis and contact dermatitis. Additionally, grapeseed oil contains antioxidants like vitamin E and polyphenols, which may help reduce oxidative stress in inflamed skin.

However, direct clinical trials specifically investigating grapeseed oil for dermatitis are scarce. Most research involves in vitro studies, animal models, or extrapolation from studies on other oils (such as sunflower or evening primrose oil) with similar fatty acid profiles. A few small studies and anecdotal reports suggest that grapeseed oil may soothe irritated skin and help with moisture retention, but robust randomized controlled trials in humans are lacking.

In summary, the use of grapeseed oil for dermatitis is scientifically plausible, and there is limited evidence supporting skin barrier benefits, but direct clinical validation is weak. It is generally considered safe for topical use but should not replace established medical treatments for dermatitis.