Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycerol monolaurate (GML) is a monoglyceride with known antimicrobial and anti-inflammatory properties. Its use in supporting or treating dermatitis is primarily supported by preclinical scientific evidence rather than traditional or long-standing medical use. In vitro and some animal studies have shown that GML can inhibit the growth of pathogenic bacteria, such as Staphylococcus aureus, which are often implicated in the exacerbation of atopic dermatitis and other skin conditions. Additionally, GML has demonstrated the ability to modulate immune responses and reduce inflammation in laboratory settings.

A few small clinical studies and case reports have explored the topical application of GML-containing formulations for skin conditions, suggesting a reduction in bacterial colonization and mild improvements in symptoms. However, large-scale, well-designed human trials are lacking, and regulatory agencies have not approved GML specifically for the treatment of dermatitis. Most commercial use of GML in this context is based on its general antimicrobial activity and its safety profile as a food additive and cosmetic ingredient. The evidence supporting its use for dermatitis is limited and primarily preclinical, so it receives a rating of 2 out of 5 for evidence strength.

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