Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids are a diverse group of phytonutrients found in many fruits, vegetables, and medicinal plants. Their use for supporting or treating dermatitis is primarily justified by scientific evidence, although much of it is preclinical or from small-scale human studies. Flavonoids possess significant antioxidant, anti-inflammatory, and immunomodulatory properties, which are relevant to the pathophysiology of dermatitis, particularly atopic dermatitis and contact dermatitis.

Several studies have demonstrated that flavonoids can inhibit the release of pro-inflammatory cytokines and mediators such as histamine, which are implicated in the inflammatory cascade of dermatitis. For example, quercetin, a well-studied flavonoid, has shown efficacy in reducing skin inflammation in animal models by stabilizing mast cells and reducing cytokine production. Other flavonoids, such as luteolin and apigenin, have also demonstrated anti-inflammatory effects relevant to skin inflammation.

Clinical evidence is still emerging. Some small clinical trials and topical preparations containing flavonoids have shown beneficial effects in reducing symptoms like redness, swelling, and itching in patients with dermatitis. However, large-scale, well-controlled human trials are lacking, and most evidence is derived from laboratory and animal studies. Thus, while scientific rationale and preliminary evidence exist, more robust clinical data are needed to fully support the use of flavonoids in dermatitis.

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