Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids are a group of polyphenolic compounds found in various fruits, vegetables, and medicinal plants. Their use in supporting or treating dermatitis is primarily justified by scientific evidence, particularly due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory properties. Several in vitro and in vivo studies have demonstrated that flavonoids can inhibit key pathways involved in skin inflammation, such as the NF-κB pathway, which is often activated in dermatitis. For example, compounds like quercetin, luteolin, and apigenin have been shown to decrease the production of pro-inflammatory cytokines and reduce oxidative stress in skin cells. Clinical evidence, though still limited, supports the beneficial effects of flavonoids in managing symptoms of atopic dermatitis and other inflammatory skin conditions. Some small-scale clinical trials and observational studies have reported improvements in skin lesions, pruritus, and erythema following topical or oral administration of flavonoid-rich formulations. However, large-scale, high-quality randomized controlled trials are still lacking, so the current level of evidence is moderate. Overall, the scientific rationale for using flavonoids in dermatitis management is based on their biological activities relevant to skin inflammation. Nevertheless, more robust clinical data is needed to fully establish their efficacy and guide standardized therapeutic use.

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