Evidence supporting the use of: Fatty acids
For the health condition: Dermatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fatty acids, particularly essential fatty acids such as omega-3 and omega-6, are supported by scientific evidence in the management of certain forms of dermatitis, especially atopic dermatitis. These fatty acids are integral components of the skin barrier, and deficiencies in linoleic acid (an omega-6 fatty acid) have been associated with impaired skin barrier function and increased transepidermal water loss, both of which are characteristic features of atopic dermatitis. Several clinical studies and reviews have examined the effects of oral supplementation and topical application of fatty acids on dermatitis symptoms. For example, randomized controlled trials have shown that supplementation with omega-3 fatty acids (such as those found in fish oil) or omega-6 fatty acids (such as evening primrose oil or borage oil) can result in modest improvements in skin hydration, itching, and overall disease severity in some individuals with atopic dermatitis.

However, the strength of the evidence is mixed. Some systematic reviews and meta-analyses have concluded that while there is a biological rationale and some positive findings, the overall effect size is small and not consistently significant across studies. In particular, topical application of fatty acids may help restore skin barrier function, but oral supplementation shows variable results depending on the patient population and the specific type of fatty acid used. As such, while there is scientific validation for the use of fatty acids in supporting dermatitis, especially atopic dermatitis, the magnitude of benefit is moderate and not universally observed.

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