Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ethyl linoleate is an ester derived from linoleic acid, an essential fatty acid known for its role in maintaining skin barrier function. Scientific research has shown that linoleic acid, and by extension some of its esters, can help restore skin barrier lipids, reduce transepidermal water loss, and exert anti-inflammatory effects, all of which are relevant to dermatitis. Several studies have highlighted the beneficial effects of topical linoleic acid in conditions like atopic dermatitis and other eczematous diseases. However, direct studies on ethyl linoleate itself are relatively limited. Some in vitro and animal studies suggest that ethyl linoleate may help reduce inflammation and promote skin healing, likely due to its ability to be hydrolyzed back to linoleic acid in the skin.

Despite these promising mechanisms, robust clinical trials specifically evaluating ethyl linoleate in human subjects with dermatitis are lacking. Most available evidence is extrapolated from the known benefits of linoleic acid. As such, while there is a reasonable scientific rationale and some preclinical support for its use, the evidence level is moderate at best, and further clinical studies are needed to establish its efficacy and safety in the treatment of dermatitis.

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