Commiphora gileadensis, also known as balm of Gilead or Mecca myrrh, has a long-standing traditional use in Middle Eastern and North African medicine for various skin ailments, including dermatitis. Historical records suggest that extracts and resins from this plant were applied topically for their purported anti-inflammatory and wound-healing properties. In traditional Arab and Jewish pharmacopoeias, preparations made from Commiphora gileadensis have been recommended for soothing irritated skin and promoting healing of minor wounds and rashes, which would encompass certain forms of dermatitis.

However, despite these traditional uses, the scientific validation for its efficacy in treating or supporting dermatitis is limited. There are a few laboratory studies indicating that extracts from related Commiphora species possess anti-inflammatory and antimicrobial properties, but direct studies on Commiphora gileadensis and its effects on human dermatitis are sparse or absent. Most evidence remains anecdotal or based on historical texts rather than on modern clinical trials.

In summary, the use of Commiphora gileadensis for dermatitis is primarily justified by traditional medicine practices, with minimal support from scientific research to date.