Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Chlorophyllin, a semi-synthetic derivative of chlorophyll, has been investigated for its use in various dermatological conditions, including dermatitis. The scientific rationale for its use primarily stems from its purported anti-inflammatory, antioxidant, and wound-healing properties. Historically, chlorophyllin has been used topically to manage wounds and ulcers due to its deodorizing and antimicrobial effects. In the context of dermatitis, especially for atopic and irritant types, evidence is limited but present. A few small clinical studies and case reports, such as those published in the mid-20th century, suggested that topical chlorophyllin might help promote healing and reduce odor in chronic skin ulcers and wounds, some of which are associated with eczematous changes or dermatitis. Modern studies are sparse, but preclinical research has indicated that chlorophyllin can reduce inflammatory markers in skin cells and may protect against oxidative stress. However, there are few high-quality, large-scale randomized controlled trials directly evaluating its efficacy in dermatitis specifically. Most support comes from its broader use in wound care and anecdotal reports rather than robust evidence targeting dermatitis as a distinct condition. Overall, while there is some scientific basis—mainly from limited human studies and preclinical data—the evidence is not strong or specific to dermatitis. Chlorophyllin’s use in dermatitis is thus justified scientifically, but the quality of evidence is modest, warranting further investigation.

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