Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caryophyllene is a bicyclic sesquiterpene found in essential oils of numerous plants, notably clove, black pepper, and cannabis. Its potential for supporting or treating dermatitis is primarily based on scientific evidence from preclinical studies. Caryophyllene is known to selectively bind to the cannabinoid receptor type 2 (CB2), which is associated with anti-inflammatory and analgesic effects. Several in vitro and animal studies have demonstrated that caryophyllene can reduce inflammation and modulate immune responses in skin tissues. For example, a 2014 study published in the journal European Journal of Pain reported that caryophyllene reduced inflammatory responses in a mouse model of contact dermatitis via CB2 receptor activation. Other studies have observed caryophyllene’s ability to decrease pro-inflammatory cytokines and support barrier function in skin models.

However, robust clinical trials in humans are lacking, and most of the evidence comes from animal or cell-based studies. There are also a few traditional uses of caryophyllene-containing plants for skin conditions, but the modern rationale hinges on its pharmacological properties and preclinical research. Thus, while the scientific basis is promising, the overall evidence remains limited and not yet conclusive for widespread therapeutic use in human dermatitis.

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