Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Beta-caryophyllene is a natural bicyclic sesquiterpene found in various essential oils, notably clove, black pepper, and cannabis. Scientific interest in beta-caryophyllene for dermatitis stems from its ability to selectively bind to the cannabinoid receptor type 2 (CB2). Activation of CB2 receptors is associated with anti-inflammatory and analgesic effects, which are beneficial in conditions like dermatitis that involve inflammation and skin barrier disruption.

Several preclinical studies have demonstrated that topical or systemic administration of beta-caryophyllene reduces skin inflammation in animal models. For example, a study published in European Journal of Pharmacology (2014) showed that beta-caryophyllene alleviated symptoms of allergic contact dermatitis in mice by reducing inflammatory cytokine production and cellular infiltration. Additional research in Phytomedicine (2020) indicated that beta-caryophyllene applied topically improved skin barrier function and reduced inflammation in models of atopic dermatitis.

While most evidence comes from animal studies or in vitro experiments, the underlying mechanisms—namely CB2 receptor activation and reduction of pro-inflammatory mediators—are well characterized. Human clinical trials are limited, but the existing data suggest potential for therapeutic use in dermatitis. Therefore, the rating of evidence is moderate (3 out of 5), reflecting promising preclinical data but a need for more robust human studies.

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