Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C has been investigated for its potential role in supporting mental health, including depression. A few observational studies and small clinical trials suggest that individuals with depression may have lower levels of Vitamin C compared to healthy controls. Furthermore, Vitamin C is a potent antioxidant, and oxidative stress is thought to contribute to the pathophysiology of depression. Some small randomized controlled trials have explored the adjunctive use of Vitamin C in depressed patients, showing modest improvements in mood symptoms, particularly when combined with conventional antidepressant therapy. For example, a 2013 double-blind study found that Vitamin C supplementation improved mood scores in hospitalized adolescent patients with depression. However, the number of well-designed, large-scale trials is limited, and the effect sizes reported are generally small. Major clinical guidelines do not currently recommend Vitamin C as a stand-alone or primary treatment for depression. Its use is more often justified as a supportive measure to correct deficiencies or as an adjunct therapy, rather than as a primary intervention. In summary, while there is some preliminary scientific evidence, it is not robust, and more research is needed to establish clear benefits.

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