Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B9, also known as folate or folic acid (when synthetic), has some scientific validation for its use as an adjunct in the treatment of depression. Research indicates that people with depression often have lower blood levels of folate compared to the general population. Several studies and meta-analyses suggest that folate supplementation, especially in the form of L-methylfolate (the bioactive form), may enhance the efficacy of certain antidepressant medications, particularly in individuals with folate deficiency or specific genetic polymorphisms (such as MTHFR mutations) that impair folate metabolism.

Randomized controlled trials have shown that L-methylfolate, when added to selective serotonin reuptake inhibitors (SSRIs), can improve depression outcomes in some patients who do not respond adequately to antidepressants alone. The mechanism is thought to involve folate’s role in the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine, which are implicated in mood regulation.

However, the evidence is not universally strong; some studies show only modest benefits, and routine supplementation in all depressed patients is not currently recommended by major guidelines. The benefit seems most pronounced in those with proven folate deficiency or relevant genetic variants. Overall, while there is scientific support for targeted use of Vitamin B9 in depression, especially as adjunctive therapy, it is not established as a primary treatment.

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