Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (pyridoxine phosphate) is scientifically linked to the support and treatment of depression, though the strength of evidence is modest. Vitamin B6 is a coenzyme involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play key roles in mood regulation. Several observational studies have found that individuals with lower levels of vitamin B6 are more likely to experience depressive symptoms. For example, cross-sectional research has shown an association between low plasma B6 and higher prevalence of depression, particularly in older adults. Some small randomized controlled trials have suggested that vitamin B6 supplementation may improve mood in certain populations, especially when there is an underlying deficiency.

However, large-scale, high-quality clinical trials directly supporting the use of vitamin B6 alone as an effective treatment for depression are limited. Most evidence comes from studies using B6 as part of a B-complex or in combination with other interventions. Treatment guidelines do not recommend vitamin B6 as a stand-alone therapy for clinical depression. In summary, while there is a plausible biological rationale and some supportive evidence, the current scientific consensus is that vitamin B6 may play a supportive role in mood regulation, especially in those with deficiency, but is not established as a primary treatment for depression.

More about Vitamin B6 (pyridoxine phosphate)
More about Depression

Other ingredients used for Depression

Other health conditions supported by Vitamin B6 (pyridoxine phosphate)

Products containing Vitamin B6 (pyridoxine phosphate)