Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) has some scientific evidence supporting its use in the context of depression, although the evidence is limited and not definitive. Vitamin B6 is a coenzyme involved in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), all of which play critical roles in mood regulation. Several observational studies have found that low levels of vitamin B6 are associated with an increased risk of depressive symptoms. For example, a 2012 cross-sectional study in older adults found that those with lower plasma B6 levels were more likely to exhibit depressive symptoms. Furthermore, some randomized controlled trials have explored the effects of vitamin B6 supplementation, often in combination with other B vitamins, on mood and depressive symptoms. Results are mixed—some studies report modest improvement in mood, while others do not find significant effects compared to placebo. The evidence for B6 as a stand-alone treatment is weaker than when it is used as part of a B-complex or in conjunction with folate and vitamin B12. Major clinical guidelines do not endorse vitamin B6 alone as a primary treatment for depression. However, supplementation may be considered in individuals with documented deficiency or as an adjunct to conventional therapies. Overall, while there is a biological rationale and some supporting data, the strength of evidence is moderate at best.

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